Hydrochloric Acid → HCID 178439349, compound

HRID 1774393Notes

Reaction equation

HRID 1774393 reaction equation
[Si]([O:8][C@H:9]1[CH2:14][CH2:13][C@H:12]([C:15]2[C:16]([O:18][C:19](=[O:24])[C:20]=2[CH:21]([CH3:23])[CH3:22])=[O:17])[CH2:11][CH2:10]1)(C(C)(C)C)(C)C.Cl.CCCCCC.C(OCC)(=O)C>C(O)C>[OH:8][C@H:9]1[CH2:10][CH2:11][C@H:12]([C:15]2[C:16]([O:18][C:19](=[O:24])[C:20]=2[CH:21]([CH3:22])[CH3:23])=[O:17])[CH2:13][CH2:14]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 21226206Ethyl acetate hexaneHCID 178439350HCID 178439350, compound

Product 1

HCID 178439349HCID 178439349, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 2-(trans-4-t-butyldimethylsilyloxycyclohexyl)-3-isopropylmaleic anhydride (263 mg, 0.745 mmol) in ethanol (7 mL) was added concentrated. hydrochloric acid (83 mg, 0.84 mmol), and the mixture was left standing at 50° C. for 30 min. The reaction mixture was directly concentrated, and the residue thus obtained was subjected to silica gel column chromatography (hexane-ethyl acetate 1:1) to give 179 mg (quantitative) of the title compound as a solid.

Workup

  1. concentrationconcentrated
  2. concentrationThe reaction mixture was directly concentrated
  3. customthe residue thus obtained

Sources & evidence

ORD record
ord-1242efe2e5ce4f3cbf273c9338bdf6a3
Source dataset
uspto-grants-2016_02
Patent number
US09260375B2

Reaction notes

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