反应详情

温度

90 °C

{1-[4-(4-Chloro-phenoxy)-phenyl]-2-isobutyl-1H-imidazol-4-yl}phenol (2 mmol) was added to a solution of Cs2CO3 (10 eq., 20 mmol) in anhydrous DMF (5 ml). This was followed by addition of the mesylate obtained above and the reaction mixture was heated to 90° C. for 2-3 h. The reaction mixture was then cooled to rt, diluted with cold water and the product was extracted with DCM. The organic layer was dried over anhydrous sodium sulfate and concentrated in vacuo to give desired phenyl ether.

1. customobtained above and the reaction mixture
2. temperatureThe reaction mixture was then cooled to rt
3. extractionthe product was extracted with DCM
4. dry with materialThe organic layer was dried over anhydrous sodium sulfate
5. concentrationconcentrated in vacuo