Hydrochloric Acid → HCID 178499981, compound

HRID 1774414Notes

Reaction equation

HRID 1774414 reaction equation
C(OC([N:8]=[C:9]([NH:34]C(OC(C)(C)C)=O)[NH:10][CH2:11][CH2:12][O:13][C:14]1[CH:33]=[CH:32][C:17]([CH2:18]/[C:19](=[C:24](\[CH:29]([CH3:31])[CH3:30])/[C:25]([O:27][CH3:28])=[O:26])/[C:20]([O:22][CH3:23])=[O:21])=[CH:16][CH:15]=1)=O)(C)(C)C.[ClH:42]>CO>[ClH:42].[CH3:23][O:22][C:20](=[O:21])/[C:19](/[CH2:18][C:17]1[CH:16]=[CH:15][C:14]([O:13][CH2:12][CH2:11][NH:10][C:9]([NH2:34])=[NH:8])=[CH:33][CH:32]=1)=[C:24](/[CH:29]([CH3:30])[CH3:31])\[C:25]([O:27][CH3:28])=[O:26]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178499980HCID 178499980, compound

Product 1

HCID 178499981HCID 178499981, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of dimethyl 2-[4-{2-[2,3-bis(t-butoxycarbonyl)guanidino]ethoxy}benzyl]-3-isopropylmaleate (23.5 mg, 0.0407 mmol) in methanol (470 μL) was added 5 M hydrochloric acid (407 μL) at room temperature, and the mixture was left standing for 4 h. The reaction mixture was concentrated to dryness to give 17.6 mg of the title compound as oil (quantitative).

Workup

  1. waitthe mixture was left
  2. concentrationThe reaction mixture was concentrated to dryness

Sources & evidence

ORD record
ord-12943eb9cc394e768490aa00986c02c1
Source dataset
uspto-grants-2016_02
Patent number
US09260375B2

Reaction notes

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