Sodium hydride → HCID 86679119, compound

HRID 1774740Notes

Reaction equation

HRID 1774740 reaction equation
[NH:1]1[CH2:6][CH2:5][S:4](=[O:8])(=[O:7])[CH2:3][CH2:2]1.[Br:9][C:10]1[CH:11]=[N:12][CH:13]=[C:14]([CH2:16]Cl)[CH:15]=1.[H-].[Na+]>>[Br:9][C:10]1[CH:15]=[C:14]([CH2:16][N:1]2[CH2:6][CH2:5][S:4](=[O:8])(=[O:7])[CH2:3][CH2:2]2)[CH:13]=[N:12][CH:11]=1

Participants

4

Reactant 3

HCID 24758Sodium hydrideHCID 6484228Thiomorpholine 1,1-dioxideHCID 117012593-Bromo-5-(chloromethyl)pyridine

Product 1

HCID 86679119HCID 86679119, compound

Procedure

In analogy to the procedure described for the preparation of intermediates A-12 [B], thiomorpholine 1,1-dioxide was reacted with 3-bromo-5-chloromethyl-pyridine (intermediate A-12 [A]) in the presence of NaH to give the title compound as a white solid. MS: 304.9, 307.0 (M+H+).

Sources & evidence

ORD record
ord-41a0b6acb3c04162b7af603efcd2f232
Source dataset
uspto-grants-2016_02
Patent number
US09260408B2

Reaction notes

Loading…