Benzylamine → N-Benzyl-6-chloropyrazin-2-amine

HRID 1774751Notes

Reaction equation

[CH2:1]([NH2:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl:9][C:10]1[CH:15]=[N:14][CH:13]=[C:12](Cl)[N:11]=1.CCN(C(C)C)C(C)C>>[CH2:1]([NH:8][C:12]1[CH:13]=[N:14][CH:15]=[C:10]([Cl:9])[N:11]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

Reactant 3

HCID 7504Benzylamine

HCID 785042,6-Dichloropyrazine

HCID 81531Diisopropylethylamine

Product 1

HCID 11708350N-Benzyl-6-chloropyrazin-2-amine

Procedure

In analogy to the procedure described for the preparation of intermediates A-20, benzyl-amine was reacted with 2,6-dichloropyrazine in presence of Hunig's base to give the title compound as a light yellow foam. MS: 220.1 (M+H+).

Sources & evidence

ORD record: ord-e232077c32204f0a9f5c58912010860d
Source dataset: uspto-grants-2016_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09260408B2

Reaction notes

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