Isopropyl iodide → HCID 86679142, compound

HRID 1774769Notes

Reaction equation

HRID 1774769 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH2:8][NH:9][S:10]([CH2:13][CH3:14])(=[O:12])=[O:11])[CH:5]=[N:6][CH:7]=1.I[CH:16]([CH3:18])[CH3:17].[H-].[Na+]>>[Br:1][C:2]1[CH:3]=[C:4]([CH2:8][N:9]([CH:16]([CH3:18])[CH3:17])[S:10]([CH2:13][CH3:14])(=[O:11])=[O:12])[CH:5]=[N:6][CH:7]=1

Participants

4

Reactant 3

HCID 6362Isopropyl iodideHCID 24758Sodium hydrideHCID 58215658N-((5-bromopyridin-3-yl)methyl)ethanesulfonamide

Product 1

HCID 86679142HCID 86679142, compound

Procedure

In analogy to the procedure described for the preparation of intermediate A-42, ethanesulfonic acid (5-bromo-pyridin-3-ylmethyl)-amide (intermediate A-11) was reacted with 2-iodopropane in presence of NaH (60% in mineral oil) to give the title compound as white solid after purification by reverse phase HPLC on a Gemini-NX column. MS: 323.1 (M+H+).

Sources & evidence

ORD record
ord-d5166e2636e442cbb4d334ff252b4b0a
Source dataset
uspto-grants-2016_02
Patent number
US09260408B2

Reaction notes

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