Methyl iodide → HCID 89440221, compound

HRID 1774770Notes

Reaction equation

HRID 1774770 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]([NH:10][S:11]([CH2:14][CH3:15])(=[O:13])=[O:12])[CH3:9])[CH:5]=[N:6][CH:7]=1.[CH3:16]I.[H-].[Na+]>>[Br:1][C:2]1[CH:3]=[C:4]([CH:8]([N:10]([CH3:16])[S:11]([CH2:14][CH3:15])(=[O:12])=[O:13])[CH3:9])[CH:5]=[N:6][CH:7]=1

Participants

4

Reactant 3

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 89440465HCID 89440465, compound

Product 1

HCID 89440221HCID 89440221, compound

Procedure

In analogy to the procedure described for the preparation of intermediate A-41, N-(1-(5-bromopyridin-3-yl)ethyl)ethanesulfonamide (intermediate A-37) was reacted with MeI in presence of NaH (60% in mineral oil) to give the title compound as a light yellow solid. MS: 307.1 and 309.2 (M+H+).

Sources & evidence

ORD record
ord-036b67e7001b4342ac539ac4e1e705c5
Source dataset
uspto-grants-2016_02
Patent number
US09260408B2

Reaction notes

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