Hydrochloric Acid → HCID 86679172, compound

HRID 1774822Notes

Reaction equation

HRID 1774822 reaction equation
C(OC([N:8]1[CH2:12][CH2:11][C@H:10]([O:13][C:14]2[CH:15]=[N:16][CH:17]=[C:18]([C:20]3[CH:21]=[C:22]4[C:27](=[CH:28][C:29]=3[F:30])[N:26]([CH3:31])[C:25](=[O:32])[CH2:24][CH2:23]4)[CH:19]=2)[CH2:9]1)=O)(C)(C)C.Cl>CO>[F:30][C:29]1[CH:28]=[C:27]2[C:22]([CH2:23][CH2:24][C:25](=[O:32])[N:26]2[CH3:31])=[CH:21][C:20]=1[C:18]1[CH:17]=[N:16][CH:15]=[C:14]([O:13][C@H:10]2[CH2:11][CH2:12][NH:8][CH2:9]2)[CH:19]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 71533569HCID 71533569, compound

Product 1

HCID 86679172HCID 86679172, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In analogy to the procedure described for the preparation of example 42, reaction of (S)-3-[5-(7-fluoro-1-methyl-2-oxo-1,2,3,4-tetrahydro-quinolin-6-yl)-pyridin-3-yloxy]-pyrrolidine-1-carboxylic acid tert-butyl ester (example 52) with hydrogen chloride (in dioxane) in methanol gave the title compound as a yellow solid. MS: 342.1 (M+H+).

Sources & evidence

ORD record
ord-b0c5e0b28ce54b658cd564d6ef1f00d5
Source dataset
uspto-grants-2016_02
Patent number
US09260408B2

Reaction notes

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