反应详情

60 mg of 3-chloroperbenzoic acid (purity of 65% or more) was added to a mixture of 40 mg of 2-(2-ethylsulfanylphenyl)-7-trifluoromethylpyrido[3,2-d]pyrimidine and 3 ml of chloroform, under ice cooling, and the mixture was stirred at room temperature for 4 hours. A 10% aqueous sodium thiosulfate solution was added to the reaction mixture, and the mixture was extracted with chloroform. The organic layer was washed with a saturated aqueous sodium bicarbonate solution and dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure to obtain 44 mg of 2-(2-ethylsulfonylphenyl)-7-trifluoromethylpyrido[3,2-d]pyrimidine (Compound of Present Invention 19).

1. extractionthe mixture was extracted with chloroform
2. washThe organic layer was washed with a saturated aqueous sodium bicarbonate solution
3. dry with materialdried over anhydrous magnesium sulfate
4. concentrationconcentrated under reduced pressure