Hydrochloric Acid → HCID 86705081, compound

HRID 1775753Notes

Reaction equation

HRID 1775753 reaction equation
[C:1](=[O:46])([O:38][CH2:39][C:40]1[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=1)[O:2][C@H:3]1[CH2:7][C@H:6]([N:8]2[CH:13]=[C:12]3[CH:14]=[C:15]([C:17]4[CH:22]=[CH:21][C:20]([CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])=[CH:19][CH:18]=4)[O:16][C:11]3=[N:10][C:9]2=[O:28])[O:5][C@@H:4]1[CH2:29][O:30][Si](C(C)(C)C)(C)C.CCOC(C)=O.Cl>CCO>[C:1](=[O:46])([O:38][CH2:39][C:40]1[CH:41]=[CH:42][CH:43]=[CH:44][CH:45]=1)[O:2][C@H:3]1[CH2:7][C@H:6]([N:8]2[CH:13]=[C:12]3[CH:14]=[C:15]([C:17]4[CH:18]=[CH:19][C:20]([CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])=[CH:21][CH:22]=4)[O:16][C:11]3=[N:10][C:9]2=[O:28])[O:5][C@@H:4]1[CH2:29][OH:30]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 8857Ethyl AcetateHCID 86705082HCID 86705082, compound

Product 1

HCID 86705081HCID 86705081, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a 10 mL flask was added 20 mg (0.2 mmol) of (2R,3S,5R)-5-(2-oxo-6-(4-pentylphenyl)furo[2,3-d]pyrimidin-3(2H)-yl)-2-((tert-butyldimethylsilyloxy)methyl)-tetrahydrofuran-3-yl benzyl carbonate, 2 mL of EtOAc, 2 mL of EtOH and 0.5 mL of 37% aqueous HCl. The mixture was stirred at rt for 0.5 h.

Sources & evidence

ORD record
ord-90ec3a9fdb3e46b0810ddcfd60be2198
Source dataset
uspto-grants-2016_02
Patent number
US09260469B2

Reaction notes

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