Hydrochloric Acid → HCID 89653161, compound

HRID 1775783Notes

Reaction equation

HRID 1775783 reaction equation
C1(C[O:8][CH2:9][CH2:10][O:11][CH2:12][CH2:13][O:14][CH2:15][CH2:16][O:17][CH2:18][CH2:19][O:20][CH2:21][CH2:22][O:23][CH2:24][CH2:25][NH:26][C:27](=[O:32])[C:28]([F:31])([F:30])[F:29])C=CC=CC=1.Cl>CO.[Pd]>[OH:8][CH2:9][CH2:10][O:11][CH2:12][CH2:13][O:14][CH2:15][CH2:16][O:17][CH2:18][CH2:19][O:20][CH2:21][CH2:22][O:23][CH2:24][CH2:25][NH:26][C:27](=[O:32])[C:28]([F:30])([F:31])[F:29]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 89653236HCID 89653236, compound

Product 1

HCID 89653161HCID 89653161, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

672 mg of compound 14 were dissolved in 5 ml of MeOH, and the solution was adjusted to a pH of 3 with HCl and, following addition of 76 mg of Pd on carbon (10%), was hydrogenated under atmospheric pressure for 17 h. The suspension was filtered over Celite, concentrated, and coevaporated twice with toluene. Solvent residues were removed overnight under an oil pump vacuum. Yield: 480 mg of colourless oil.

Workup

  1. filtrationThe suspension was filtered over Celite
  2. concentrationconcentrated
  3. customSolvent residues were removed overnight under an oil pump vacuum

Sources & evidence

ORD record
ord-78f04d0db562439082d36f3f45f6eb6f
Source dataset
uspto-grants-2016_02
Patent number
US09260467B2

Reaction notes

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