Formaldehyde → HCID 57930458, compound

HRID 1775921Notes

Reaction equation

HRID 1775921 reaction equation
Cl.F[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[NH:9]N.[CH2:11](OC(OCC)CCCNC)C.[F:23][C:24]1[CH:25]=[CH:26][CH:27]=[C:28]2[C:32]=1[NH:31][CH:30]=[C:29]2[CH2:33][CH2:34][NH:35][CH3:36].C=O.[C:39]([OH:45])([C:41](F)(F)F)=O>C(#N)C.FC1C=CC=C2C=1NC1CN(C)CCC2=1.CC1C=CC(C2CO2)=CN=1.[H-].[Na+]>[F:23][C:24]1[CH:25]=[CH:26][CH:27]=[C:28]2[C:32]=1[N:31]([CH2:41][CH:39]([C:7]1[CH:6]=[N:9][C:4]([CH3:5])=[CH:3][CH:8]=1)[OH:45])[C:30]1[CH2:36][N:35]([CH3:11])[CH2:34][CH2:33][C:29]2=1

Participants

10

Reactant 5

HCID 712FormaldehydeHCID 6422Trifluoroacetic acidHCID 2723910Hydrazine, (2-fluorophenyl)-, hydrochloride (1:1)HCID 139945474,4-Diethoxy-N-methylbutan-1-amineHCID 57825658HCID 57825658, compound

Product 1

HCID 57930458HCID 57930458, compound

Reagents, catalysts & solvents 4

HCID 6342AcetonitrileSolventHCID 24758Sodium hydrideSolventHCID 157135882-Methyl-5-(oxiran-2-yl)pyridineSolventHCID 66911646HCID 66911646, compoundSolvent

Procedure

The title compound is prepared by following General Methods 3, 4 and 8 by using 2-fluorophenylhydrazine hydrochloride and 4,4-diethoxy-N-methylbutan-1-amine (General Method 3), 2-(7-fluoro-1H-indol-3-yl)-N-methylethanamine, formaldehyde and TFA in acetonitrile (General Method 4) and 8-fluoro-2,3,4,9-tetrahydro-2-methyl-1H-pyrido[3,4-b]indole, 2-methyl-5-(oxiran-2-yl)pyridine and NaH (General Method 8).

Sources & evidence

ORD record
ord-fb1e6d8f9e6e4aad88b0c04d19452a98
Source dataset
uspto-grants-2016_02
Patent number
US09260429B2

Reaction notes

Loading…