Formaldehyde → HCID 44242380, compound

HRID 1775940Notes

Reaction equation

HRID 1775940 reaction equation
Cl.Cl[C:3]1C=CC(NN)=CC=1.BrCCCC1C=NC=CC=1.ClC1C=CC(N(CCCC2C=NC=CC=2)N)=CC=1.C(OC(OCC)CCCNC)C.[Cl:51][C:52]1[CH:53]=[C:54]2[C:58](=[CH:59][CH:60]=1)[N:57]([CH2:61][CH2:62][CH2:63][C:64]1[CH:65]=[N:66][CH:67]=[CH:68][CH:69]=1)[CH:56]=[C:55]2[CH2:70][CH2:71][NH:72][CH3:73].C=O.C(O)(C(F)(F)F)=O>C(#N)C.C(N(CC)CC)C>[Cl:51][C:52]1[CH:53]=[C:54]2[C:58](=[CH:59][CH:60]=1)[N:57]([CH2:61][CH2:62][CH2:63][C:64]1[CH:65]=[N:66][CH:67]=[CH:68][CH:69]=1)[C:56]1[CH2:73][N:72]([CH3:3])[CH2:71][CH2:70][C:55]2=1

Participants

10

Reactant 7

HCID 712FormaldehydeHCID 6422Trifluoroacetic acidHCID 71600Hydrazine, (4-chlorophenyl)-, hydrochloride (1:1)HCID 127015683-(3-Bromopropyl)pyridineHCID 139945474,4-Diethoxy-N-methylbutan-1-amineHCID 66911723HCID 66911723, compoundHCID 66911794HCID 66911794, compound

Product 1

HCID 44242380HCID 44242380, compound

Reagents, catalysts & solvents 2

HCID 6342AcetonitrileSolventHCID 8471TriethylamineSolvent

Procedure

The title compound is prepared by following General Methods 1, 3 and 4 using 4-chlorophenylhydrazine hydrochloride, 3-(3-bromopropyl)pyridine, and triethylamine (General Method 1), 1-(4-chlorophenyl)-1-(3-(pyridin-3-yl)propyl)hydrazine and 4,4-diethoxy-N-methylbutan-1-amine (General Method 3) and 2-(5-chloro-1-(3-(pyridin-3-yl)propyl)-1H-indol-3-yl)-N-methylethanamine, formaldehyde and TFA in acetonitrile (General Method 4).

Sources & evidence

ORD record
ord-dc9c601926c84367ada02beae0e9e7ee
Source dataset
uspto-grants-2016_02
Patent number
US09260429B2

Reaction notes

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