Formaldehyde → HCID 44242437, compound

HRID 1775941Notes

Reaction equation

HRID 1775941 reaction equation
Cl.Cl[C:3]1C=CC(NN)=CC=1.BrCCCC1C=CC(C(F)(F)F)=NC=1.ClC1C=CC(N(CCCC2C=NC(C(F)(F)F)=CC=2)N)=CC=1.C(OC(OCC)CCCNC)C.[Cl:59][C:60]1[CH:61]=[C:62]2[C:66](=[CH:67][CH:68]=1)[N:65]([CH2:69][CH2:70][CH2:71][C:72]1[CH:73]=[N:74][C:75]([C:78]([F:81])([F:80])[F:79])=[CH:76][CH:77]=1)[CH:64]=[C:63]2[CH2:82][CH2:83][NH:84][CH3:85].C=O.C(O)(C(F)(F)F)=O>C(#N)C.C(N(CC)CC)C>[Cl:59][C:60]1[CH:61]=[C:62]2[C:66](=[CH:67][CH:68]=1)[N:65]([CH2:69][CH2:70][CH2:71][C:72]1[CH:73]=[N:74][C:75]([C:78]([F:81])([F:80])[F:79])=[CH:76][CH:77]=1)[C:64]1[CH2:85][N:84]([CH3:3])[CH2:83][CH2:82][C:63]2=1

Participants

10

Reactant 7

HCID 712FormaldehydeHCID 6422Trifluoroacetic acidHCID 71600Hydrazine, (4-chlorophenyl)-, hydrochloride (1:1)HCID 139945474,4-Diethoxy-N-methylbutan-1-amineHCID 668695135-(3-Bromopropyl)-2-(trifluoromethyl)pyridineHCID 66911629HCID 66911629, compoundHCID 66911642HCID 66911642, compound

Product 1

HCID 44242437HCID 44242437, compound

Reagents, catalysts & solvents 2

HCID 6342AcetonitrileSolventHCID 8471TriethylamineSolvent

Procedure

The title compound is prepared by following General Methods 1, 3 and 4 using 4-chlorophenylhydrazine hydrochloride, 5-(3-bromopropyl)-2-(trifluoromethyl)pyridine, and triethylamine (General Method 1), 1-(4-chlorophenyl)-1-(3-(6-(trifluoromethyl)pyridin-3-yl)propyl)hydrazine and 4,4-diethoxy-N-methylbutan-1-amine (General Method 3) and 2-(5-chloro-1-(3-(6-(trifluoromethyl)pyridin-3-yl)propyl)-1H-indol-3-yl)-N-methylethanamine, formaldehyde and TFA in acetonitrile (General Method 4).

Sources & evidence

ORD record
ord-a61a39fbdd2f4f60b783e5c100a47293
Source dataset
uspto-grants-2016_02
Patent number
US09260429B2

Reaction notes

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