Dimethylformamide → tert-butyl 4-ethyl-4-(5-oxopyrrolo[4,3,2-de][2,6]naphthyridin-4(1H,3H,5H)-yl)piperidine-1-carboxylate

HRID 177723Notes

Reaction equation

HRID 177723 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][C:11]([CH2:14][CH3:15])([NH:16][CH2:17][c:18]2[cH:19][nH:20][c:21]3[n:22][cH:23][cH:24][c:25]([C:27](=[O:28])[OH:29])[c:26]23)[CH2:12][CH2:13]1.[CH3:54][N:55]([CH3:56])[c:57]1[cH:58][cH:59][n:60][cH:61][cH:62]1.[O:63]=[CH:64][N:65]([CH3:66])[CH3:67].[P-:30]([F:31])([F:32])([F:33])([F:34])([F:35])[F:36].[n:37]1([O:38][C:39]([N:40]([CH3:41])[CH3:42])=[N+:43]([CH3:44])[CH3:45])[c:46]2[n:47][cH:48][cH:49][cH:50][c:51]2[n:52][n:53]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][C:11]([CH2:14][CH3:15])([N:16]2[CH2:17][c:18]3[cH:19][nH:20][c:21]4[n:22][cH:23][cH:24][c:25]([c:26]34)[C:27]2=[O:29])[CH2:12][CH2:13]1

Participants

6

Reactant 5

HCID 6228DimethylformamideHCID 9886HexafluorophosphateHCID 142844-(Dimethylamino)pyridineHCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminiumHCID 672237873-((1-(tert-butoxycarbonyl)-4-ethylpiperidin-4-ylamino)methyl)-1H-pyrrolo[2,3-b]pyridine-4-carboxylic acid

Product 1

HCID 49841775tert-butyl 4-ethyl-4-(5-oxopyrrolo[4,3,2-de][2,6]naphthyridin-4(1H,3H,5H)-yl)piperidine-1-carboxylate

Sources & evidence

ORD record
ord-e37db4d9dfd5497bac30447a76e66b47
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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