反应详情

温度

67.5 °C

Potassium carbonate (0.16 g, 0.0012 mol) and 4-methylpiperidine-4-carboxylic acid ethyl ester (0.21 g, 0.0012 mol) are added to a solution of 5-(3-chloro-4-cyclohexylphenyl)-3-(4-chloromethylphenyl)-[1,2,4]-oxadiazole (0.3 g, 0.00077 mol) in N,N-dimethylformamide 15 mL). The reaction mixture is heated at 65-70° C. for 2 hrs. Removal of solvent gives a crude residue which is purified by column chromatography (silica gel 230-400 mesh, ethyl acetate:toluene, 1:4) to give 4-methyl-1-{4-[5-(3-chloro-4-cyclohexylphenyl)-[1,2,4]-oxadiazol-3-yl]benzyl}piperidine-4-carboxylic acid ethyl ester.

1. customRemoval of solvent
2. customgives a crude residue which
3. customis purified by column chromatography (silica gel 230-400 mesh, ethyl acetate:toluene, 1:4)