Ethyl oxoacetate → HCID 118020502, compound

HRID 1777385Notes

Reaction equation

HRID 1777385 reaction equation
[NH2:1][CH2:2][CH:3]([CH3:6])[CH2:4][OH:5].[C:7]([O:11][CH2:12][CH3:13])(=[O:10])[CH:8]=O.[CH3:14][C:15]1[CH:16]=[CH:17][C:18]([N:24]2[N:28]=[CH:27][CH:26]=[N:25]2)=[C:19]([CH:23]=1)[C:20](O)=[O:21]>C1(C)C=CC=CC=1>[CH3:6][CH:3]1[CH2:4][O:5][CH:8]([C:7]([O:11][CH2:12][CH3:13])=[O:10])[N:1]([C:20](=[O:21])[C:19]2[CH:23]=[C:15]([CH3:14])[CH:16]=[CH:17][C:18]=2[N:24]2[N:28]=[CH:27][CH:26]=[N:25]2)[CH2:2]1

Participants

5

Reactant 3

HCID 70211Ethyl oxoacetateHCID 101976253-amino-2-methylpropan-1-olHCID 532601655-methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid

Product 1

HCID 118020502HCID 118020502, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

By using 3-amino-2-methylpropan-1-ol (0.10 g, 1.1 mmol), ethyl glyoxylate (polymer type, a solution of 47% toluene) (2.0 mL, 9.7 mmol) and 5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid (0.5 g, 2.5 mmol), the same procedure as in Reference Example 1 was carried out to obtain the title compound (0.13 g) (colorless oil).

Sources & evidence

ORD record
ord-4fb2f892bb1f48e5863fb6756a515198
Source dataset
uspto-grants-2016_02
Patent number
US09266870B2

Reaction notes

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