Hydrochloric Acid → HCID 67973906, compound

HRID 1777533Notes

Reaction equation

HRID 1777533 reaction equation
[OH-].[Na+].[F:3][C:4]1[CH:13]=[C:12]([CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([F:21])[CH:16]=2)[CH:11]=[CH:10][C:5]=1[C:6]([O:8]C)=[O:7].Cl>C(O)C>[F:3][C:4]1[CH:13]=[C:12]([CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([F:21])[CH:16]=2)[CH:11]=[CH:10][C:5]=1[C:6]([OH:8])=[O:7]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 67974606HCID 67974606, compound

Product 1

HCID 67973906HCID 67973906, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of sodium hydroxide 2M (1 mL; 2 mmol) was added to a solution of methyl 2-fluoro-4-(3-fluorobenzyl)benzoate (0.151 g; 0.576 mmol) in ethanol (1 mL). The mixture was stirred at room temperature for 1 hour and the pH of the solution was adjusted to 1 by addition of a solution of 6N hydrochloric acid. The precipitate was collected by filtration and dried under reduced pressure to give 0.141 g (99%) of 2-fluoro-4-(3-fluorobenzyl)benzoic acid as a white solid.

Workup

  1. filtrationThe precipitate was collected by filtration
  2. customdried under reduced pressure

Sources & evidence

ORD record
ord-ab2cb2ea66c649678c7a9c3542ebb187
Source dataset
uspto-grants-2016_02
Patent number
US09266832B2

Reaction notes

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