Tetrahydrofuran → 2-(3-bromo-2-oxopyrrolidin-1-yl)-N-(4-fluorobenzyl)-4-methylthiazole-5-carboxamide
Reaction equation
[Br:34][N:35]1[C:36](=[O:37])[CH2:38][CH2:39][C:40]1=[O:41].[CH3:24][Si:25]([N-:26][Si:27]([CH3:28])([CH3:29])[CH3:30])([CH3:31])[CH3:32].[F:1][c:2]1[cH:3][cH:4][c:5]([CH2:6][NH:7][C:8](=[O:9])[c:10]2[c:11]([CH3:21])[n:12][c:13]([N:15]3[C:16](=[O:20])[CH2:17][CH2:18][CH2:19]3)[s:14]2)[cH:22][cH:23]1.[Li+:33].[O:42]1[CH2:43][CH2:44][CH2:45][CH2:46]1>>[F:1][c:2]1[cH:3][cH:4][c:5]([CH2:6][NH:7][C:8](=[O:9])[c:10]2[c:11]([CH3:21])[n:12][c:13]([N:15]3[C:16](=[O:20])[CH:17]([Br:34])[CH2:18][CH2:19]3)[s:14]2)[cH:22][cH:23]1Participants
6
Sources & evidence
- ORD record
- ord-ff30105ce0844e92907aa28cb9f8d4b0
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (6/10)
Reaction notes
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