4-Piperidinol, 1-methyl- → 6-Amino-4-((1-methylpiperidin-4-yl)oxy)nicotinonitrile

HRID 1777894Notes

Reaction equation

HRID 1777894 reaction equation
[NH2:1][C:2]1[CH:9]=[C:8](F)[C:5]([C:6]#[N:7])=[CH:4][N:3]=1.[CH3:11][N:12]1[CH2:17][CH2:16][CH:15]([OH:18])[CH2:14][CH2:13]1>>[NH2:1][C:2]1[CH:9]=[C:8]([O:18][CH:15]2[CH2:16][CH2:17][N:12]([CH3:11])[CH2:13][CH2:14]2)[C:5]([C:6]#[N:7])=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 660484-Piperidinol, 1-methyl-HCID 1180369016-Amino-4-fluoronicotinonitrile

Product 1

HCID 1180361816-Amino-4-((1-methylpiperidin-4-yl)oxy)nicotinonitrile

Procedure

From intermediate 21 and 1-methylpiperidin-4-ol, reacted in an analogous manner to the preparation of intermediate 45. (UPLC-MS 3) tR 0.30 min; ESI-MS 233.2 [M+H]+.

Sources & evidence

ORD record
ord-e1177d68ef754be2ae566d2d4ad0a9b5
Source dataset
uspto-grants-2016_02
Patent number
US09266883B2

Reaction notes

Loading…