Isobutanol → HCID 118036774, compound

HRID 1777948Notes

Reaction equation

HRID 1777948 reaction equation
[NH2:1][C:2]1[CH:9]=[C:8](F)[C:5]([C:6]#[N:7])=[CH:4][N:3]=1.[CH3:11][CH:12]([CH3:15])[CH2:13][OH:14]>>[NH2:1][C:2]1[CH:9]=[C:8]([O:14][CH2:13][CH:12]([CH3:15])[CH3:11])[C:5]([C:6]#[N:7])=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 6560IsobutanolHCID 1180369016-Amino-4-fluoronicotinonitrile

Product 1

HCID 118036774HCID 118036774, compound

Procedure

From intermediate 21 and 2-methylpropan-1-ol, reacted in an analogous manner to the preparation of intermediate 89. 1H NMR (400 MHz, DMSO-d6) δ 8.13 (s, 1H), 7.86 (s, br, 2H), 6.04 (s, 1H), 3.79 (d, 2H), 2.06-1.96 (m, 1H), 0.96 (d, 6H).

Sources & evidence

ORD record
ord-46a545715578426aaeb73bbadec95fcd
Source dataset
uspto-grants-2016_02
Patent number
US09266883B2

Reaction notes

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