反应详情

A solution of tert-butyl 3-hydroxyazetidine-1-carboxylate (2.0 g), DMAP (1.55 g) and triethylamine (2.34 g) in DCM (80 mL) was cooled to 0° C. A solution of acetic anhydride (2.35 g) in DCM (20 mL) was added dropwise over 20 minutes and the reaction mixture was stirred at room temperature for 1 hour. The mixture was washed with water and brine, dried (MgSO4) and filtered. The filtrate was concentrated in vacuo and the residue was dissolved in ether and washed with 10% aqueous citric acid solution and brine, dried (MgSO4), filtered. The filtrate was concentrated in vacuo to give tert-butyl 3-acetoxyazetidine-1-carboxylate (2.34 g) as a clear oil.

1. washThe mixture was washed with water and brine
2. dry with materialdried (MgSO4)
3. filtrationfiltered
4. concentrationThe filtrate was concentrated in vacuo
5. dissolutionthe residue was dissolved in ether
6. washwashed with 10% aqueous citric acid solution and brine
7. dry with materialdried (MgSO4)
8. filtrationfiltered
9. concentrationThe filtrate was concentrated in vacuo