Potassium Carbonate → HCID 117697932, compound

HRID 1778533Notes

Reaction equation

HRID 1778533 reaction equation
[CH2:1]([N:8]1[CH:13]2[C:14]([F:17])([F:16])[CH2:15][CH:9]1[CH2:10][CH:11](CC([O-])=O)[CH2:12]2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C([O-])([O-])=[O:23].[K+].[K+]>CO>[CH2:1]([N:8]1[CH:13]2[C:14]([F:17])([F:16])[CH2:15][CH:9]1[CH2:10][CH:11]([OH:23])[CH2:12]2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 131734828HCID 131734828, compound

Product 1

HCID 117697932HCID 117697932, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of compound 116f (1.48 g, 4 mmol, 1.0 eq) and K2CO3 (1.1 g, 8 mmol, 2.0 eq) in MeOH (20 mL) was stirred at room temperature for 16 h. The mixture was quenched with water (100 mL), extracted with EA (100 mL) two times, the organic layer was combined, dried over Na2SO4 and concentrated to give 8-benzyl-6,6-difluoro-8-azabicyclo[3.2.1]octan-3-ol 116g as a colorless oil, 1.02 g, crude yield: 100° A. MS: calc'd (MH+) 254, measured (MH+) 254.

Workup

  1. customThe mixture was quenched with water (100 mL)
  2. extractionextracted with EA (100 mL) two times
  3. dry with materialdried over Na2SO4
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-f745ba06813b43169b4ca96f3568dd85
Source dataset
uspto-grants-2016_02
Patent number
US09266904B2

Reaction notes

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