Trifluoroacetic acid → HCID 117697841, compound

HRID 1778540Notes

Reaction equation

HRID 1778540 reaction equation
[CH2:1]([O:3][C:4](=[O:23])[CH2:5][CH:6]1[CH2:13][CH:12]2[N:14](C(OC(C)(C)C)=O)[CH:8]([CH2:9][O:10][CH2:11]2)[CH:7]1[OH:22])[CH3:2].FC(F)(F)C(O)=O>ClCCl>[OH:22][CH:7]1[CH:6]([CH2:5][C:4]([O:3][CH2:1][CH3:2])=[O:23])[CH2:13][CH:12]2[NH:14][CH:8]1[CH2:9][O:10][CH2:11]2

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 117697824HCID 117697824, compound

Product 1

HCID 117697841HCID 117697841, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of compound 123d (100 mg) in dichloromethane (2.0 mL) was added trifluoroacetic acid (1.0 mL). The reaction mixture was stirred at room temperature for one hour, and concentrated under reduced pressure to give ethyl 2-(6-hydroxy-3-oxa-9-azabicyclo[3.3.1]nonan-7-yl)acetate 123a, which was used directly in next step without purification.

Workup

  1. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-75d670500ab64065ae6c5c78d4f18a63
Source dataset
uspto-grants-2016_02
Patent number
US09266904B2

Reaction notes

Loading…