Trifluoroacetic acid → HCID 178493519, compound

HRID 1778677Notes

Reaction equation

HRID 1778677 reaction equation
C(O)(C(F)(F)F)=O.[F:8][C:9]1[C:14]([O:15][CH3:16])=[CH:13][C:12]([O:17][CH3:18])=[C:11]([F:19])[C:10]=1[C:20]1[N:25]=[C:24]2[NH:26][N:27]=[C:28](I)[C:23]2=[CH:22][N:21]=1.[CH3:30][N:31]1[CH2:36][CH2:35][N:34]([C:37]2[CH:42]=[C:41](B3OC(C)(C)C(C)(C)O3)[CH:40]=[CH:39][N:38]=2)[CH2:33][CH2:32]1>>[F:8][C:9]1[C:14]([O:15][CH3:16])=[CH:13][C:12]([O:17][CH3:18])=[C:11]([F:19])[C:10]=1[C:20]1[N:25]=[C:24]2[NH:26][N:27]=[C:28]([C:41]3[CH:40]=[CH:39][N:38]=[C:37]([N:34]4[CH2:33][CH2:32][N:31]([CH3:30])[CH2:36][CH2:35]4)[CH:42]=3)[C:23]2=[CH:22][N:21]=1

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 27695372-(4-Methylpiperazin-1-yl)pyridine-4-boronic acid, pinacol esterHCID 178493522HCID 178493522, compound

Product 1

HCID 178493519HCID 178493519, compound

Procedure

This compound was prepared as TFA salt by using procedures analogous to those described for the synthesis of Example 7, Step 3 starting from 6-(2,6-difluoro-3,5-dimethoxyphenyl)-3-iodo-1H-pyrazolo[3,4-d]pyrimidine and 1-methyl-4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]piperazine. LCMS (M+H)+=468.1.

Sources & evidence

ORD record
ord-15d1ed33567d40fdb708afdc782b75fd
Source dataset
uspto-grants-2016_02
Patent number
US09266892B2

Reaction notes

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