反应详情

温度

40 °C

A mixture of methyl 5-bromo-3-(bromomethyl)pyridine-2-carboxylate (0.39 g, 1.3 mmol), ethylamine in THF (0.88 mL, 2.0 M, 1.8 mmol) and potassium carbonate (0.26 g, 1.9 mmol) in ethanol (5 mL) in a sealed reaction vial was stirred at 40° C. for 2 h. The solid was filtered off. The filtrate was concentrated under reduced pressure. The residue was purified by flash chromatography on a silica gel column with ethyl acetate in hexanes (0-50%) to afford the desired product (0.24 g). LCMS (M+H)+=240.9/242.9.

1. customin a sealed reaction vial
2. filtrationThe solid was filtered off
3. concentrationThe filtrate was concentrated under reduced pressure
4. customThe residue was purified by flash chromatography on a silica gel column with ethyl acetate in hexanes (0-50%)