2-Methoxyethylamine → 5-Bromo-2-(2-methoxyethyl)isoindolin-1-one

HRID 1778744Notes

Reaction equation

HRID 1778744 reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([O-:8])=O)=[C:4]([CH2:11]Br)[CH:3]=1.[CH3:13][O:14][CH2:15][CH2:16][NH2:17]>>[Br:1][C:2]1[CH:3]=[C:4]2[C:5](=[CH:9][CH:10]=1)[C:6](=[O:8])[N:17]([CH2:16][CH2:15][O:14][CH3:13])[CH2:11]2

Participants

3

Reactant 2

HCID 80182-MethoxyethylamineHCID 231581454-Bromo-2-(bromomethyl)benzoate

Product 1

HCID 592763025-Bromo-2-(2-methoxyethyl)isoindolin-1-one

Procedure

This compound was prepared by using procedures analogous to those described for the synthesis of Example 52, Step 6 starting from 4-bromo-2-(bromomethyl)benzoate (AstaTech Cat. No. 27012) and 2-methoxyethylamine (Aldrich Cat No. 241067). LCMS (M+H)+=270.0/272.0.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-b4525711ad4e48e8bb17c63b63fe4a39
Source dataset
uspto-grants-2016_02
Patent number
US09266892B2

Reaction notes

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