Hydrochloric Acid → HCID 23534457, compound

HRID 1778930Notes

Reaction equation

HRID 1778930 reaction equation
[CH:1]1([S:7](Cl)(=[O:9])=[O:8])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:11][NH2:12].Cl>>[CH3:11][NH:12][S:7]([CH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1)(=[O:9])=[O:8]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 6329MethylamineHCID 237554Cyclohexanesulfonyl chloride

Product 1

HCID 23534457HCID 23534457, compound

Procedure

Cyclohexanesulfonyl chloride (500 mg) was added to methylamine (12.3 mL, 2M solution in tetrahydrofuran) and the reaction mixture was stirred at room temperature for one hour. The solution was added to 1M aqueous HCl and extracted with ethyl acetate. The extract was washed with brine and dried over anhydrous sodium sulfate. After filtration, the solvent was removed under vacuum to yield the product.

Workup

  1. extractionextracted with ethyl acetate
  2. washThe extract was washed with brine
  3. dry with materialdried over anhydrous sodium sulfate
  4. filtrationAfter filtration
  5. customthe solvent was removed under vacuum
  6. customto yield the product

Sources & evidence

ORD record
ord-4ed81d72bde84336a0d29769787a6e76
Source dataset
uspto-grants-2016_02
Patent number
US09266877B2

Reaction notes

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