Sulfuric Acid → 20389-05-3

HRID 1779360Notes

Reaction equation

HRID 1779360 reaction equation
[OH-].[Na+].[NH:3]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:6](=O)[C:4]1=[O:5].[CH3:14][C:15]1[CH:20]=[CH:19][C:18]([C:21]([CH3:23])=O)=[CH:17][CH:16]=1.S(=O)(=O)(O)[OH:25]>C(O)C>[CH3:14][C:15]1[CH:20]=[CH:19][C:18]([C:21]2[CH:23]=[C:6]([C:4]([OH:25])=[O:5])[C:8]3[C:13](=[CH:12][CH:11]=[CH:10][CH:9]=3)[N:3]=2)=[CH:17][CH:16]=1

Participants

6

Reactant 4

HCID 1118Sulfuric AcidHCID 7054IsatinHCID 8500p-METHYLACETOPHENONEHCID 14798Sodium Hydroxide

Product 1

HCID 62186720389-05-3

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Ten milliliters (2.2N) of a sodium hydroxide aqueous solution was added dropwise to an ethanol (20 ml) suspension containing 1.47 g of isatin and 2.67 ml of 4-methylacetophenone at room temperature, and the reaction mixture was then heat-refluxed for 5.5 hours. The resulting reaction mixture was allowed to cool, and then acidified with 2N sulfuric acid to obtain an orange-colored precipitate. This precipitate was collected by filtration, and dried to form 2.34 g of the above-mentioned compound.

Workup

  1. temperaturethe reaction mixture was then heat-refluxed for 5.5 hours
  2. customThe resulting reaction mixture
  3. temperatureto cool
  4. customto obtain an orange-colored precipitate
  5. filtrationThis precipitate was collected by filtration
  6. customdried

Sources & evidence

ORD record
ord-7581e411d58c4807ae38596384704825
Source dataset
uspto-grants-1997_05
Patent number
US05627193

Reaction notes

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