Hydrochloric Acid → HCID 178424155, compound

HRID 1779365Notes

Reaction equation

HRID 1779365 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:17]=[C:16]([C:18]([NH:20][C:21]([NH2:23])=[NH:22])=[O:19])[C:15]2[C:10](=[CH:11][C:12]([O:24]COC)=[CH:13][CH:14]=2)[N:9]=1.Cl.[OH-].[Na+]>C(O)(C)C>[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:17]=[C:16]([C:18]([NH:20][C:21]([NH2:23])=[NH:22])=[O:19])[C:15]2[C:10](=[CH:11][C:12]([OH:24])=[CH:13][CH:14]=2)[N:9]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 178497285HCID 178497285, compound

Product 1

HCID 178424155HCID 178424155, compoundYield 50.6%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

2-(2'-Methylphenyl)-7-methoxymethyloxyquinoline-4-carbonylguanidine (0.9 g) formed in Example 45 was heat-stirred in 20 ml (0.5M) of an isopropyl alcohol solution of hydrochloric acid at approximately 60° C. for 3.5 hours. The reaction mixture was allowed to cool, then neutralized with a 5% sodium hydroxide aqueous solution, and concentrated. The residue was filtered, and the crystals obtained were washed with water, and dried to obtain 0.40 g of the above-mentioned compound as a brown crystal. m.p. 202°-208° C.

Workup

  1. temperatureto cool
  2. concentrationconcentrated
  3. filtrationThe residue was filtered
  4. customthe crystals obtained
  5. washwere washed with water
  6. customdried

Sources & evidence

ORD record
ord-01d23bcc9f264ddc8795d1876c5de87f
Source dataset
uspto-grants-1997_05
Patent number
US05627193

Reaction notes

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