Hydroxyamine hydrochloride → HCID 86750792, compound

HRID 1779485Notes

Reaction equation

HRID 1779485 reaction equation
[S:1]1[C:5]2[C:6](=O)[C:7]3[N:8]([CH:9]=[CH:10][CH:11]=3)[C:4]=2[CH:3]=[CH:2]1.Cl.[NH2:14][OH:15]>N1C=CC=CC=1>[OH:15][N:14]=[C:6]1[C:5]2[S:1][CH:2]=[CH:3][C:4]=2[N:8]2[CH:9]=[CH:10][CH:11]=[C:7]12

Participants

4

Reactant 2

HCID 443297Hydroxyamine hydrochlorideHCID 13070727HCID 13070727, compound

Product 1

HCID 86750792HCID 86750792, compoundYield 82.8%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Heat at reflux for 90 minutes a solution of 0.011 mol of 8H-thieno[2,3-d]pyrrolo[1,2-a]pyrrol-8-one (Preparation 28) and 0.0132 mol of hydroxylamine hydrochloride in 50 ml of pyridine. After cooling and after removal of the pyridine under reduced pressure, the residue is taken up in 150 ml of water and extracted with diethyl ether. The ethereal solution is dried over magnesium sulfate and then concentrated under reduced pressure to yield the title compound in the form of a mixture comprising 70% of the Z form, 30% of the E form.

Workup

  1. temperatureHeat
  2. temperatureAfter cooling
  3. customafter removal of the pyridine under reduced pressure
  4. extractionextracted with diethyl ether
  5. dry with materialThe ethereal solution is dried over magnesium sulfate
  6. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-508be72f70f44fc9b5f68c75f6d03883
Source dataset
uspto-grants-1997_05
Patent number
US05627203

Reaction notes

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