Hydrochloric Acid → HCID 22872482, compound

HRID 1779502Notes

Reaction equation

HRID 1779502 reaction equation
C[O:2][C:3](=[O:24])[C@@H:4]1[CH2:8][CH2:7][CH2:6][N:5]1[CH:9]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[C@@H:10]1[C@@H:14]([CH2:15][CH3:16])[CH2:13][CH2:12][NH:11]1.[OH-].[Na+].Cl>CO>[C:20]([O:19][C:17]([CH:9]([C@@H:10]1[C@@H:14]([CH2:15][CH3:16])[CH2:13][CH2:12][NH:11]1)[N:5]1[CH2:6][CH2:7][CH2:8][C@H:4]1[C:3]([OH:24])=[O:2])=[O:18])([CH3:23])([CH3:22])[CH3:21]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 22872483HCID 22872483, compound

Product 1

HCID 22872482HCID 22872482, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
0 °C

Procedure

N-[(tert-Butyloxy)carbonyl-3(S)-ethylpyrrolidin-2(S)-ylmethyl]-proline methyl ester 0.081 g, 0.238 mmol) was dissolved in CH3OH (2 mL), cooled to 0° C. and treated with 1N NaOH solution (0.952 mL, 0.952 mmol). After stirring at 23° C. for 3 h, the solution was neutralized with 1N HCl (0.952 mL, 0.952 mmol), concentrated to remove the CH3OH, then lyophilized and the residue used as is.

Workup

  1. concentrationconcentrated
  2. customto remove the CH3OH

Sources & evidence

ORD record
ord-9663fda3e90e4f8eae565c94a0fcf7fa
Source dataset
uspto-grants-1997_05
Patent number
US05627202

Reaction notes

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