Hydrochloric Acid → HCID 19956430, compound

HRID 1779529Notes

Reaction equation

HRID 1779529 reaction equation
[CH2:1]([N:4](C(OC(C)(C)C)=O)[CH2:5][CH2:6][CH2:7][N:8](C(OC(C)(C)C)=O)[CH2:9]/[CH:10]=[CH:11]/[CH2:12][N:13](C(OC(C)(C)C)=O)[CH2:14][CH2:15][CH2:16][N:17]([CH2:25][CH2:26][CH3:27])C(OC(C)(C)C)=O)[CH2:2][CH3:3].[ClH:49]>C(OCC)C>[ClH:49].[ClH:49].[ClH:49].[ClH:49].[CH2:25]([NH:17][CH2:16][CH2:15][CH2:14][NH:13][CH2:12]/[CH:11]=[CH:10]/[CH2:9][NH:8][CH2:7][CH2:6][CH2:5][NH:4][CH2:1][CH2:2][CH3:3])[CH2:26][CH3:27]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 19956403HCID 19956403, compound

Product 1

HCID 19956430HCID 19956430, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A mixture of 1.26 g (1.84 mmol) of (E)-1,14-di-propyl-1,5,10,14-tetra-BOC-1,5,10,14-tetraazatetradec-7-ene and 19 ml of 3N methanolic hydrochloric acid is stirred for 15 h at room temperature. The reaction mixture is then diluted with 19 ml of diethyl ether, the mixture is filtered, and the filtration residue is washed with diethyl ether. Drying under a high vacuum at 100° C. yields the crystalline title compound (m.p. >260° C.). 1H-NMR (D2O): δ0.95(t,6H); 1.62-1.75(m,4H); 2.05-2.16(m,4H); 3.02(t,4H); 3.11-3.18(m,8H); 3.76(d,4H); 6.04-6.06(m,2H).

Workup

  1. filtrationthe mixture is filtered
  2. washthe filtration residue is washed with diethyl ether
  3. customDrying under a high vacuum at 100° C.

Sources & evidence

ORD record
ord-f4ddb784fda241b0900965479a19cb14
Source dataset
uspto-grants-1997_05
Patent number
US05627215

Reaction notes

Loading…