Trichloroacetic Acid → HCID 54097936, compound

HRID 1779922Notes

Reaction equation

HRID 1779922 reaction equation
[Br:1][CH:2]1[CH2:31][C@@H:30]([CH3:32])[CH2:29][O:28][C@@:3]21[C@@H:7]([CH3:8])[C@@H:6]1[C@:9]3([CH3:27])[C@@H:22]([CH2:23][C@@H:5]1[O:4]2)[C@H:21]1[C@@H:12]([C@:13]2([CH3:25])[C@@H:18]([CH2:19][CH2:20]1)[CH2:17][C@@H:16]([OH:24])[CH2:15][CH2:14]2)[C@H:11]1[O:26][C@@H:10]31.[Cl:33][C:34]([Cl:39])([Cl:38])[C:35]([OH:37])=[O:36]>C1(C)C=CC=CC=1>[Br:1][CH:2]1[CH2:31][C@@H:30]([CH3:32])[CH2:29][O:28][C@@:3]21[C@@H:7]([CH3:8])[C@@H:6]1[C@:9]3([CH3:27])[C@@H:22]([CH2:23][C@@H:5]1[O:4]2)[C@H:21]1[C@@H:12]([C@:13]2([CH3:25])[C@@H:18]([CH2:19][CH2:20]1)[CH2:17][C@@H:16]([OH:24])[CH2:15][CH2:14]2)[C@@H:11]([OH:26])[C@@H:10]3[O:36][C:35](=[O:37])[C:34]([Cl:39])([Cl:38])[Cl:33]

Participants

4

Reactant 2

HCID 6421Trichloroacetic AcidHCID 86750802HCID 86750802, compound

Product 1

HCID 54097936HCID 54097936, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

Using the procedure described in J. Chem. Soc., 1956, 4330, (3β,5α,11β,12β,25R)-23-bromo-11,12-epoxyspirostan-3-ol was treated with trichloroacetic acid in toluene at room temperature for 3 days to give the title compound.

Sources & evidence

ORD record
ord-bb0af9c4b769443fbc6377d7ccbe1886
Source dataset
uspto-grants-1997_05
Patent number
US05629295

Reaction notes

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