Water → HCID 178526530, compound

HRID 1779986Notes

Reaction equation

HRID 1779986 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][CH:3]=1.[NH:11]1[CH:15]=NC=[N:12]1.C(=O)([O-])[O-].[K+].[K+].O.[CH3:23][N:24]1CCCC1=O>>[NH:24]1[CH:23]=[C:15]([C:2]2[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][CH:3]=2)[N:11]=[N:12]1

Participants

6

Reactant 5

HCID 962WaterHCID 92571H-1,2,4-TriazoleHCID 9590p-FluoronitrobenzeneHCID 11430Potassium CarbonateHCID 13387N-methyl-2-pyrrolidone

Product 1

HCID 178526530HCID 178526530, compoundYield 85%

Conditions

Temperature
100 °C

Procedure

A 7 g portion of 4-fluoronitrobenzene, 7 g of 1,2,4-triazole and 7.6 g of potassium carbonate were dissolved in 40 ml of N-methylpyrrolidone and stirred at 100° C. for 4 hours. After cooling to room temperature, the reaction solution was poured into water and extracted with ethyl acetate. After washing with 1N hydrochloric acid and water in that order and subsequent drying, the solvent was removed by evaporation under a reduced pressure to obtain 8 g of 4-triazolylnitrobenzene with a yield of 85%.

Workup

  1. temperatureAfter cooling to room temperature
  2. extractionextracted with ethyl acetate
  3. washAfter washing with 1N hydrochloric acid and water in that order and subsequent drying
  4. customthe solvent was removed by evaporation under a reduced pressure

Sources & evidence

ORD record
ord-effbf9189aab49a5bb5f55118029ea47
Source dataset
uspto-grants-1997_05
Patent number
US05629332

Reaction notes

Loading…