HCID 19065244, compound → HCID 19049275, compound

HRID 1780017Notes

Reaction equation

HRID 1780017 reaction equation
[CH2:1]([C:4]1[C:5]([O:28][CH2:29][C:30]2[O:31][C:32]([CH3:36])([CH3:35])[O:33][CH:34]=2)=[CH:6][C:7]2[O:12][C:11]([C:13]3[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[C:15]([OH:21])[C:14]=3[CH2:22][CH:23]=[CH2:24])=[CH:10][C:9](=[O:25])[C:8]=2[C:26]=1[OH:27])[CH:2]=[CH2:3]>CN(C)C=O>[OH:27][C:26]1[C:8]2[C:9](=[O:25])[CH:10]=[C:11]([C:13]3[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[C:15]([OH:21])[C:14]=3[CH2:22][CH2:23][CH3:24])[O:12][C:7]=2[CH:6]=[C:5]([O:28][CH2:29][C:30]2[O:31][C:32]([CH3:36])([CH3:35])[O:33][CH:34]=2)[C:4]=1[CH2:1][CH2:2][CH3:3]

Participants

3

Reactant 1

HCID 19065244HCID 19065244, compound

Product 1

HCID 19049275HCID 19049275, compoundYield 99.2%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

2.4 g of the compound of Example 27 are hydrogenated in 40 ml of dimethylformamide with 100 mg of catalyst (5% palladium-on-carbon) under a hydrogen pressure of 6300 hPa. After absorption of the theoretical amount of hydrogen, the mixture is filtered over Millipore and the filtrate is distilled under reduced pressure. The residue yields 2.4 g of the expected product which is used as it is. An analytical sample was prepared by recrystallisation from isopropanol, m.p. 148° C.

Workup

  1. customAfter absorption of the theoretical amount of hydrogen
  2. filtrationthe mixture is filtered over Millipore
  3. distillationthe filtrate is distilled under reduced pressure

Sources & evidence

ORD record
ord-32b58ac5be034b74af1463722090494a
Source dataset
uspto-grants-1997_05
Patent number
US05629339

Reaction notes

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