2-Morpholinoethylamine → HCID 86750831, compound

HRID 1780260Notes

Reaction equation

Br[CH2:2][C:3]([NH:5][C:6]1[CH:48]=[CH:47][C:9]([O:10][CH2:11][C:12]([NH:14][C@H:15]([C:20]([NH:22][C@@H:23]([CH2:40][C:41]2[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=2)[C@H:24]([OH:39])[C:25]([N:27]2[CH2:38][CH2:37][CH2:36][C@H:28]2[C:29]([NH:31][C:32]([CH3:35])([CH3:34])[CH3:33])=[O:30])=[O:26])=[O:21])[CH2:16][C:17](=[O:19])[NH2:18])=[O:13])=[CH:8][CH:7]=1)=[O:4].[NH2:49][CH2:50][CH2:51][N:52]1[CH2:57][CH2:56][O:55][CH2:54][CH2:53]1>>[O:55]1[CH2:56][CH2:57][N:52]([CH2:51][CH2:50][NH:49][CH2:2][C:3]([NH:5][C:6]2[CH:48]=[CH:47][C:9]([O:10][CH2:11][C:12]([NH:14][C@H:15]([C:20]([NH:22][C@@H:23]([CH2:40][C:41]3[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=3)[C@H:24]([OH:39])[C:25]([N:27]3[CH2:38][CH2:37][CH2:36][C@H:28]3[C:29]([NH:31][C:32]([CH3:35])([CH3:34])[CH3:33])=[O:30])=[O:26])=[O:21])[CH2:16][C:17](=[O:19])[NH2:18])=[O:13])=[CH:8][CH:7]=2)=[O:4])[CH2:53][CH2:54]1

Participants

Reactant 2

HCID 4082852-Morpholinoethylamine

HCID 86750830HCID 86750830, compound

Product 1

HCID 86750831HCID 86750831, compound

Procedure

Following a procedure similar to that described in Example 38, but using 100 mg (0.137 mmol) of 1-{(2S,3S)-3-[N2 -(4-bromoacetamidophenoxy)acetyl-L-asparaginyl]amino-2-hydroxy-4-phenylbutyryl}-N-t-butyl-L-prolinamide and 1 ml of 4-(2-aminoethyl)morpholine, 17 mg of the title compound were obtained as a colorless powder, melting at 123°-132° C.

Sources & evidence

ORD record: ord-d72e1be878c14e0aa9365d5caf9fc1ec
Source dataset: uspto-grants-1997_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05629406

Reaction notes

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