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HRID1780366

反应详情

EQUATION

反应方程式

HRID 1780366 的结构方程式

REACTANTS

反应物

4
结构：c1ccc(P(c2ccccc2)c2ccccc2)cc1
HCID11776

Triphenylphosphine

C18H15P

结构：CC(C)(C)OC(=O)N1CCC[C@H]1CO
HCID643448

N-Boc-L-prolinol

C10H19NO3

结构：CCOC(=O)/N=N/C(=O)OCC
HCID5462977

(E)-Diethyl azodicarboxylate

C6H10N2O4

结构：Oc1cnc(F)c(Br)c1
HCID18458777

5-Bromo-6-fluoropyridin-3-ol

C5H3BrFNO

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)N1CCC[C@H]1COc1cnc(F)c(Br)c1
HCID22872670

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：C1CCOC1
溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

A sample of 1-BOC-2-(S)-pyrrolidinemethanol, prepared as described above, and of 3-bromo-2-fluoro-5-hydroxypyridine, prepared as in step b above, are reacted with triphenylphosphine and DEAD in THF at room temperature for 16 hours, to give the title compound.