反应详情

0.20 g (0.5 mmol) of 2-chloro-3-octyl-6-(4-octyloxyphenyl)pyridine is heated together with 0.5 g of potassium fluoride, 0.5 g sodium fluoride and 0.02 g of 18-crown-6 in a sealed tube at 200° C. for 18 hours. The reaction mixture is taken up in ether/water, the organic phase is washed with water, dried over sodium sulfate, filtered, the solvent is distilled off, the residue is purified by chromatography (silica gel, 8:2 hexane/ethyl acetate) and recrystallized from acetonitrile, giving 0.11 g of 2-fluoro-3-octyl-6- (4-octyloxyphenyl ) pyridine. ##STR16##

1. washthe organic phase is washed with water
2. dry with materialdried over sodium sulfate
3. filtrationfiltered
4. distillationthe solvent is distilled off
5. customthe residue is purified by chromatography (silica gel, 8:2 hexane/ethyl acetate)
6. customrecrystallized from acetonitrile