反应详情

2.30 g (13.35 mmol) of diethyl azodicarboxylate are added dropwise at 0° C. to 3.47 g (13.35 mmol) of triphenylphosphine in 100 ml of tetrahydrofuran, and the mixture is stirred at room temperature for 30 minutes. 3.58 g (8.10 mmol) of 6-(4-tert.-butyldiphenylsilyloxyphenyl)-2-fluoro-3-hydroxypyridine and 1.70 g (13.35 mmol) of 1-octanol are then added. After a reaction time of 1.5 hours at room temperature, the solvent is distilled off, and the residue is purified by chromatography (silica gel, 95:5 hexane/ethyl acetate), giving 4.43 g of 6-(4-tert.-butyldiphenylsilyloxyphenyl)-2-fluoro-3-octyloxypyridine. ##STR46##

1. distillationAfter a reaction time of 1.5 hours at room temperature, the solvent is distilled off
2. customthe residue is purified by chromatography (silica gel, 95:5 hexane/ethyl acetate)