Methyl iodide → HCID 10784665, compound

HRID 1780655Notes

Reaction equation

HRID 1780655 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]2[O:9][C:10]3[CH:16]=[CH:15][CH:14]=[CH:13][C:11]=3[N:12]=2)[CH2:4][CH2:3]1.[CH3:17][I:18]>CN(C=O)C>[I-:18].[CH3:1][N+:2]1([CH3:17])[CH2:3][CH2:4][N:5]([C:8]2[O:9][C:10]3[CH:16]=[CH:15][CH:14]=[CH:13][C:11]=3[N:12]=2)[CH2:6][CH2:7]1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 37945392-(4-methylpiperazino)-1,3-benzoxazole

Product 1

HCID 10784665HCID 10784665, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A 435 mg portion of 2-(4-methyl-1-piperazinyl)benzoxazole was dissolved in 6 ml of DMF. Under cooling with ice, 0.19 ml of methyl iodide was added to the thus prepared solution, and the reaction was carried out for 1 hour at the same temperature and then for 1 hour at room temperature. The reaction solution was concentrated under a reduced pressure, and 4 ml of acetone was added to the resulting residue. The precipitate thus formed was collected by filtration, washed with acetone and then dried to obtain 670 mg of the title compound.

Workup

  1. additionwas added to the thus prepared solution
  2. waitfor 1 hour at room temperature
  3. concentrationThe reaction solution was concentrated under a reduced pressure, and 4 ml of acetone
  4. additionwas added to the resulting residue
  5. customThe precipitate thus formed
  6. filtrationwas collected by filtration
  7. washwashed with acetone
  8. customdried

Sources & evidence

ORD record
ord-16f574230a564d7885fbe1f21c3bf2d8
Source dataset
uspto-grants-1997_05
Patent number
US05631257

Reaction notes

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