Allyl iodide → HCID 19047274, compound

HRID 1780678Notes

Reaction equation

HRID 1780678 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]2[O:9][C:10]3[CH:16]=[C:15]([N+:17]([O-:19])=[O:18])[CH:14]=[CH:13][C:11]=3[N:12]=2)[CH2:4][CH2:3]1.[CH2:20]([I:23])[CH:21]=[CH2:22]>CN(C=O)C>[I-:23].[CH2:20]([N+:2]1([CH3:1])[CH2:7][CH2:6][N:5]([C:8]2[O:9][C:10]3[CH:16]=[C:15]([N+:17]([O-:19])=[O:18])[CH:14]=[CH:13][C:11]=3[N:12]=2)[CH2:4][CH2:3]1)[CH:21]=[CH2:22]

Participants

4

Reactant 2

HCID 11166Allyl iodideHCID 10611487HCID 10611487, compound

Product 1

HCID 19047274HCID 19047274, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Under cooling with ice, 50 mg of 2-(4-methyl-1-piperazinyl)-6-nitrobenzoxazole dissolved in 5 ml of DMF was mixed with 0.021 ml of allyl iodide, and the reaction was carried out for 1 hour at the same temperature and then for 19 hours at room temperature. The reaction mixture was concentrated under a reduced pressure, and the resulting residue was purified by Sephadex LH-20 (Pharmacia) (chloroform:methanol=1:1) to obtain 67 mg of the title compound.

Workup

  1. waitfor 19 hours at room temperature
  2. concentrationThe reaction mixture was concentrated under a reduced pressure
  3. customthe resulting residue was purified by Sephadex

Sources & evidence

ORD record
ord-eb69a8df42864050b40d6cf4523fd9ae
Source dataset
uspto-grants-1997_05
Patent number
US05631257

Reaction notes

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