Hydrochloric Acid → HCID 67711044, compound

HRID 1781250Notes

Reaction equation

HRID 1781250 reaction equation
[CH2:1]([N:4]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[N:7]=[C:6]([NH2:14])[C:5]1=[O:15])[CH2:2][CH3:3].[ClH:16]>C(O)C>[ClH:16].[CH2:1]([N:4]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[N:7]=[C:6]([NH2:14])[C:5]1=[O:15])[CH2:2][CH3:3]

Participants

4

Reactant 2

HCID 313Hydrochloric Acid2×HCID 23195105HCID 23195105, compound

Product 1

HCID 67711044HCID 67711044, compoundYield 80%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The crystals of compound 4 obtained above are suspended in ethanol. An ethanolic solution of hydrogen chloride gas is then added: the base dissolves and the hydrochloride then begins to precipitate out. After cooling and dilution with ethyl ether, the crystals are filtered off and then washed with a 50/50 ethanol/ethyl ether mixture, and then with ethyl ether. After drying, 4.25 g (yield 80%) of compound 5 are recovered in the form of white crystals.

Workup

  1. dissolutionthe base dissolves
  2. customto precipitate out
  3. temperatureAfter cooling
  4. filtrationdilution with ethyl ether, the crystals are filtered off
  5. washwashed with a 50/50 ethanol/ethyl ether mixture
  6. customAfter drying

Sources & evidence

ORD record
ord-55ff37946a134630811817199fc061c1
Source dataset
uspto-grants-1997_05
Patent number
US05633255

Reaction notes

Loading…