Piperidine → HCID 86746769, compound

HRID 1781421Notes

Reaction equation

HRID 1781421 reaction equation
[CH3:1][S:2]([NH:5][C:6]1[CH:7]=[CH:8][C:9]2[O:27][C:13]3([CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C:21]4[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=4)[CH2:15][CH2:14]3)[CH2:12][C:11](=O)[C:10]=2[CH:29]=1)(=[O:4])=[O:3].Cl.[NH2:31][OH:32].N1CCCCC1>>[CH3:1][S:2]([NH:5][C:6]1[CH:7]=[CH:8][C:9]2[O:27][C:13]3([CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C:21]4[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=4)[CH2:15][CH2:14]3)[CH2:12][C:11](=[N:31][OH:32])[C:10]=2[CH:29]=1)(=[O:4])=[O:3]

Participants

4

Reactant 3

HCID 8082PiperidineHCID 443297Hydroxyamine hydrochlorideHCID 10409553HCID 10409553, compound

Product 1

HCID 86746769HCID 86746769, compound

Procedure

In the manner of Example 427, 3,4-dihydro-6-methane-sulfonamido-1'-(2-phenylethyl)-spiro[(2H)-benzopyran-2,4'-piperidine]-4-one was treated with hydroxylamine hydrochloride to give, after chromatography, the piperidine as a solid, m.p. 95°-99° C.

Workup

  1. customto give

Sources & evidence

ORD record
ord-279cdd14781f41258a183f976b3f293e
Source dataset
uspto-grants-1997_05
Patent number
US05633247

Reaction notes

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