反应详情

温度

70 °C

Diphenylacetaldehyde (25.6 g), acrylonitrile (12.5 ml), and 1,8-diazabicyclo[5,4,0]undec-7-ene (DBU:2.5 g) were stirred in isopropyl alcohol (250 ml) with warming at 70° C. for 6 hours. The reaction mixture was concentrated to dryness and the group was purified by silica gel column chromatography. The crude crystal crop obtained was washed with isopropyl ether to provide the title compound (19.8 g) as colorless crystals.

1. concentrationThe reaction mixture was concentrated to dryness
2. customthe group was purified by silica gel column chromatography
3. customThe crude crystal crop obtained
4. washwas washed with isopropyl ether