Selenium Dioxide → HCID 104763, compound

HRID 1781569Notes

Reaction equation

[Se](=O)=O.C[C@H]1[C@H](O)C(=O)O[CH2:31][C@:23]23[C@H:28]([O:29][C@H:20]4[C@:21]5(O[CH2:38]5)[C@:22]2([CH3:37])[C@@H:18]([CH2:19]4)OC(=O)C=CC=CC(=O)OCC1)[CH:27]=[C:26]([CH3:30])[CH2:25][CH2:24]3>>[CH3:38][CH:21]1[C@@:22]2([CH3:37])[C@:23]3([CH3:31])[C@H:28]([O:29][C@@H:20]1[CH2:19][CH2:18]2)[CH:27]=[C:26]([CH3:30])[CH2:25][CH2:24]3

Participants

Reactant 2

HCID 24007Selenium Dioxide

HCID 6326658Verrucarin A

Product 1

HCID 104763HCID 104763, compound

Procedure

The trichothecene therapeutic agent 16-oxo verrucarin A is prepared by selenium dioxide oxidation of verrucarin A. The MAb hydrazide is then reacted with 16-oxo verrucarin A at 4° C. overnight with agitation, thereby yielding a unique Schiff base-linked targeting protein having the following structure: ##STR19##

Sources & evidence

ORD record: ord-ab73c212c79c45b8805584012da837d6
Source dataset: uspto-grants-1997_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05633351

Reaction notes

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