反应详情

A mixture of 4-amino-benzonitrile (12.5 g, 0.106 mol), 2,2-dimethyl-[1,3]dioxane-4,6-dione (18.3 g, 0.127 mol) and trimethylorthoformate (16 ml) in ethanol (100 ml) was refluxed for 3 hours. After cooling the solid was filtered off, washed with ethanol and air dried. The product was obtained as an off-white solid (27.9 g, 97%).

1. temperaturewas refluxed for 3 hours
2. temperatureAfter cooling the solid
3. filtrationwas filtered off
4. washwashed with ethanol and air
5. customdried