反应详情

温度

20 °C

3H-spiro[2-benzofuran-1,4′-piperidine] (5 g, 26 mmol) was dissolved in THF (100 mL) and cooled in ice. Then N-ethyldiisopropylamine (4.94 mL, 29 mmol) and chloroacetyl chloride (2.31 mL, 29 mmol) were added. The mixture was stirred at 20° C. for 15 min. The solid was filtered off and washed with THF. The filtrate was evaporated to dryness and the residue was purified by flash chromatography on silica gel with heptane/AcOEt 70:30. One obtained light yellow crystals (6.5 g, 92%). MS: m/z=266 [M+H]+.

1. temperaturecooled in ice
2. filtrationThe solid was filtered off
3. washwashed with THF
4. customThe filtrate was evaporated to dryness
5. customthe residue was purified by flash chromatography on silica gel with heptane/AcOEt 70:30