Ammonium Chloride → 5-Bromo-2-(2H-tetrazol-5-yl)pyridine

HRID 1782084Notes

Reaction equation

HRID 1782084 reaction equation
[Br:1][C:2]1[CH:3]=[N:4][C:5]([C:8]#[N:9])=[CH:6][CH:7]=1.[N-:10]=[N+:11]=[N-:12].[Na+].[Cl-].[NH4+]>CN(C)C=O.C(OCC)(=O)C>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[NH:12][N:11]=[N:10][N:9]=2)=[N:4][CH:3]=1

Participants

6

Reactant 3

HCID 25517Ammonium ChlorideHCID 33557Sodium AzideHCID 8171545-Bromopyridine-2-carbonitrile

Product 1

HCID 234386835-Bromo-2-(2H-tetrazol-5-yl)pyridine

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolventHCID 8857Ethyl AcetateSolvent

Conditions

Temperature
120 °C

Procedure

A mixture of 3-bromo-6-cyano-pyridine (2 g, 10.9 mmol), sodium azide (0.85 g, 13 mmol), and ammonium chloride (0.59 g, 11 mmol) in N,N-dimethylformamide (20 mL) was heated for 1 h at 120° C. The reaction mixture was diluted with ethyl acetate (˜100 mL) and the product was isolated by filtration and then washed with ethyl acetate to give the title compound, an off-white amorphous solid which was used in the next step without further purification.

Workup

  1. customthe product was isolated by filtration
  2. washwashed with ethyl acetate

Sources & evidence

ORD record
ord-f08ba27cbfad482bb60f59a43d1dedba
Source dataset
uspto-grants-2009_03
Patent number
US07498350B2

Reaction notes

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