Dimethyl Sulfoxide → 2-Methyl-1-(phenylsulfonyl)-1H-pyrrole-3-carbaldehyde

HRID 1782234Notes

Reaction equation

HRID 1782234 reaction equation
[CH3:1][C:2]1[N:3]([S:9]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)(=[O:11])=[O:10])[CH:4]=[CH:5][C:6]=1[CH2:7][OH:8].CS(C)=O.C(=O)([O-])O.[Na+]>C(N(CC)CC)C>[CH3:1][C:2]1[N:3]([S:9]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)(=[O:10])=[O:11])[CH:4]=[CH:5][C:6]=1[CH:7]=[O:8]

Participants

5

Reactant 3

HCID 679Dimethyl SulfoxideHCID 516892Sodium BicarbonateHCID 66924976[2-methyl-1-(phenylsulfonyl)-1H-pyrrol-3-yl]methanol

Product 1

HCID 862328242-Methyl-1-(phenylsulfonyl)-1H-pyrrole-3-carbaldehydeYield 84%

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

To a mixture of [2-methyl-1-(phenylsulfonyl)-1H-pyrrol-3-yl]methanol (6.35 g), dimethyl sulfoxide (50 mL) and triethylamine (25 mL) was added sulfur trioxide-pyridine complex (4.57 g), and the mixture was stirred at room temperature for 12 hr. Saturated aqueous sodium hydrogencarbonate solution was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The extract as washed with saturated aqueous sodium hydrogencarbonate solution, water and saturated brine, dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: hexane-ethyl acetate=2:1) to give a white title compound (yield 5.27 g, 84%).

Workup

  1. additionwas added sulfur trioxide-pyridine complex (4.57 g)
  2. extractionthe mixture was extracted with ethyl acetate
  3. extractionThe extract
  4. washas washed with saturated aqueous sodium hydrogencarbonate solution, water and saturated brine
  5. dry with materialdried over anhydrous sodium sulfate
  6. filtrationfiltered
  7. concentrationconcentrated under reduced pressure
  8. customThe residue was purified by silica gel column chromatography (eluent: hexane-ethyl acetate=2:1)

Sources & evidence

ORD record
ord-018c2b5f131e41e688d594a36866654a
Source dataset
uspto-grants-2009_03
Patent number
US07498337B2

Reaction notes

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